Discovery of Small-Molecule Degraders of the CDK9-Cyclin T1 Complex for Targeting Transcriptional Addiction in Prostate Cancer

Author:

Li Jiacheng12,Liu Ting3,Song Yuanli24,Wang Mingyu12,Liu Liping12,Zhu Hongwen24,Li Qi12,Lin Jin3,Jiang Hualiang12,Chen Kaixian12,Zhao Kehao5,Wang Mingliang1,Zhou Hu24ORCID,Lin Hua16ORCID,Luo Cheng3127ORCID

Affiliation:

1. The Center for Chemical Biology, Drug Discovery and Design Center, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China

2. University of Chinese Academy of Sciences, No.19A Yuquan Road, Beijing 100049, China

3. School of Pharmacy, Fujian Medical University, Fuzhou 350122, China

4. Department of Analytical Chemistry and CAS Key Laboratory of Receptor Research, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zuchongzhi Road, Shanghai 201203, China

5. School of Pharmacy, Key Laboratory of Molecular Pharmacology and Drug Evaluation (Yantai University), Ministry of Education, Collaborative Innovation Center of Advanced Drug Delivery System and Biotech Drugs in Universities of Shandong, Yantai University, Yantai 264005, China

6. Biomedical Research Center of South China, College of Life Sciences, Fujian Normal University, Fuzhou 350117, China

7. School of Life Science and Technology, ShanghaiTech University, 100 Haike Road, Shanghai 201210, China

Funder

Ministry of Science and Technology of the People's Republic of China

Natural Science Foundation of Fujian Province

Taishan Scholar Project of Shandong Province

Science and Technology Commission of Shanghai Municipality

National Natural Science Foundation of China

Fujian Normal University

Top Talents Program for One Case Discussion of Shandong Province

State Key Laboratory of Drug Research

National Multidisciplinary Innovation Team of Traditional Chinese Medicine

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

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