Isolation, Structural Identification, Synthesis, and Pharmacological Profiling of 1,2-trans-Dihydro-1,2-diol Metabolites of the Utrophin Modulator Ezutromid-Reference-Cited by-同舟云学术

Isolation, Structural Identification, Synthesis, and Pharmacological Profiling of 1,2-trans-Dihydro-1,2-diol Metabolites of the Utrophin Modulator Ezutromid

Published:2019-10-10 Issue:5 Volume:63 Page:2547-2556
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Chatzopoulou Maria¹^ORCID,Claridge Tim D. W.¹^ORCID,Davies Kay E.²,Davies Stephen G.¹^ORCID,Elsey David J.³,Emer Enrico¹,Fletcher Ai M.¹,Harriman Shawn⁴,Robinson Neil⁵,Rowley Jessica A.¹,Russell Angela J.¹⁶^ORCID,Tinsley Jonathon M.³,Weaver Richard⁷,Wilkinson Isabel V. L.¹,Willis Nicky J.¹,Wilson Francis X.³,Wynne Graham M.¹

Affiliation:

1. Department of Chemistry, University of Oxford, Chemistry Research Laboratory, Mansfield Road, Oxford OX1 3TA, United Kingdom

2. Department of Physiology, Anatomy and Genetics, MDUK Oxford Neuromuscular Centre, University of Oxford, Oxford OX1 3PT, United Kingdom

3. Summit Therapeutics plc, 136a Eastern Avenue, Milton Park, Abingdon OX14 4SB, United Kingdom

4. Summit Therapeutics plc, One Broadway, 14th Floor, Cambridge, Massachusetts 02142, United States

5. S.H.B. Enterprises Ltd., 55 Station Road, Beaconsfield HP19 1QL, United Kingdom

6. Department of Pharmacology, University of Oxford, Mansfield Road, Oxford OX1 3PQ, United Kingdom

7. XenoGesis Ltd., BioCity Nottingham, Pennyfoot Street, Nottingham NG1 1GF, United Kingdom

Funder

Engineering and Physical Sciences Research Council

Medical Research Council

Duchenne UK

Summit Therapeutics plc

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.9b01547

Reference39 articles.

1. Population frequencies of inherited neuromuscular diseases—A world survey

2. Advances in Duchenne muscular dystrophy gene therapy

3. Function and Genetics of Dystrophin and Dystrophin-Related Proteins in Muscle

4. Dystrophin: The protein product of the duchenne muscular dystrophy locus

5. Pharmacological advances for treatment in Duchenne muscular dystrophy

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