Development of Highly Potent, G-Protein Pathway Biased, Selective, and Orally Bioavailable GPR84 Agonists-Reference-Cited by-同舟云学术

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Development of Highly Potent, G-Protein Pathway Biased, Selective, and Orally Bioavailable GPR84 Agonists

Published:2023-12-26 Issue:1 Volume:67 Page:110-137
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Wang Pinqi¹²,Raja Arun¹²,Luscombe Vincent B.³^ORCID,Bataille Carole J. R.¹²,Lucy Daniel¹³,Rogga Vanessa V.¹,Greaves David R.³,Russell Angela J.¹²^ORCID

Affiliation:

1. Department of Chemistry, University of Oxford, Mansfield Road, Oxford OX1 3TA, U.K.

2. Department of Pharmacology, University of Oxford, Mansfield Road, Oxford OX1 3QT, U.K.

3. Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford OX1 3RE, U.K.

Funder

Erasmus+

British Heart Foundation

H2020 Marie Sklodowska-Curie Actions

University of Oxford

Guy Newton Translational Fund

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.3c00951

Reference53 articles.

1. Coding GPCR-G protein specificity

2. The structure and function of G-protein-coupled receptors

3. Complex Pharmacology of Free Fatty Acid Receptors

4. The Orphan G Protein-coupled Receptor GPR40 Is Activated by Medium and Long Chain Fatty Acids

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