Profile of a Highly Selective Quaternized Pyrrolidine Betaine αvβ6 Integrin Inhibitor—(3S)-3-(3-(3,5-Dimethyl-1H-pyrazol-1-yl)phenyl)-4-((1S and 1R,3R)-1-methyl-3-(2-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)ethyl)pyrrolidin-1-ium-1-yl)butanoate Synthesized by Stereoselective Methylation-Reference-Cited by-同舟云学术

Profile of a Highly Selective Quaternized Pyrrolidine Betaine αvβ6 Integrin Inhibitor—(3S)-3-(3-(3,5-Dimethyl-1H-pyrazol-1-yl)phenyl)-4-((1S and 1R,3R)-1-methyl-3-(2-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)ethyl)pyrrolidin-1-ium-1-yl)butanoate Synthesized by Stereoselective Methylation

Published:2019-08-05 Issue:16 Volume:62 Page:7543-7556
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Barrett Tim N.¹,Taylor Jonathan A.¹,Barker Daniel¹,Procopiou Panayiotis A.¹^ORCID,Thompson James D. F.¹²,Barrett John¹,Le Joelle¹,Lynn Sean M.¹,Pogany Peter¹,Pratley Cassie¹,Pritchard John M.¹,Roper James A.¹,Rowedder James E.¹,Slack Robert J.¹,Vitulli Giovanni¹,Macdonald Simon J. F.¹^ORCID,Kerr William J.²^ORCID

Affiliation:

1. Medicinal Science & Technology, GlaxoSmithKline Medicines Research Centre, Gunnels Wood Road, Stevenage, SG1 2NY, United Kingdom

2. Department of Pure & Applied Chemistry, University of Strathclyde, 295 Cathedral Street, Glasgow, G1 1XL, U.K.

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.9b00819

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1. Dissecting fibrosis: therapeutic insights from the small-molecule toolbox

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