Dissecting fibrosis: therapeutic insights from the small-molecule toolbox-Reference-Cited by-同舟云学术

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Dissecting fibrosis: therapeutic insights from the small-molecule toolbox

Published:2015-09-04 Issue:10 Volume:14 Page:693-720
ISSN:1474-1776
Container-title:Nature Reviews Drug Discovery
language:en
Short-container-title:Nat Rev Drug Discov

Author:

Nanthakumar Carmel B.,Hatley Richard J. D.,Lemma Seble,Gauldie Jack,Marshall Richard P.,Macdonald Simon J. F.

Publisher

Springer Science and Business Media LLC

Subject

Drug Discovery,Pharmacology,General Medicine

Link

http://www.nature.com/articles/nrd4592.pdf

Reference304 articles.

1. Raghu, G., Weycker, D., Edelsberg, J., Bradford, W. Z. & Oster, G. Incidence and prevalence of idiopathic pulmonary fibrosis. Am. J. Respir. Crit. Care Med. 174, 810–816 (2006).

2. Olson, A. L. et al. Mortality from pulmonary fibrosis increased in the United States from 1992 to 2003. Am. J. Respir. Crit. Care Med. 176, 277–284 (2007).

3. Allison, M. Stromedix acquisition signals growing interest in fibrosis. Nat. Biotechnol. 30, 375–376 (2012).

4. King, T. E. Jr. et al. A phase 3 trial of pirfenidone in patients with idiopathic pulmonary fibrosis. N. Engl. J. Med. 370, 2083–2092 (2014). This article reports pivotal Phase III data for pirfenidone in patients with IPF; these data subsequently led to FDA approval of the drug as Esbriet in the United States.

5. Datta, A., Scotton, C. J. & Chambers, R. C. Novel therapeutic approaches for pulmonary fibrosis. Br. J. Pharmacol. 163, 141–172 (2011).

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