Identification of CNS-Penetrant Aryl Sulfonamides as Isoform-Selective NaV1.6 Inhibitors with Efficacy in Mouse Models of Epilepsy-Reference-Cited by-同舟云学术

Identification of CNS-Penetrant Aryl Sulfonamides as Isoform-Selective NaV1.6 Inhibitors with Efficacy in Mouse Models of Epilepsy

Published:2019-09-17 Issue:21 Volume:62 Page:9618-9641
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Focken Thilo¹^ORCID,Burford Kristen¹,Grimwood Michael E.¹,Zenova Alla¹,Andrez Jean-Christophe¹,Gong Wei¹,Wilson Michael¹,Taron Matt¹,Decker Shannon¹,Lofstrand Verner¹,Chowdhury Sultan¹,Shuart Noah¹,Lin Sophia¹,Goodchild Samuel J.¹,Young Clint¹,Soriano Maegan¹,Tari Parisa K.¹,Waldbrook Matthew¹,Nelkenbrecher Karen¹,Kwan Rainbow¹,Lindgren Andrea¹,de Boer Gina¹,Lee Stephanie¹,Sojo Luis¹,DeVita Robert J.²,Cohen Charles J.¹,Wesolowski Steven S.¹,Johnson J. P.¹,Dehnhardt Christoph M.¹^ORCID,Empfield James R.¹

Affiliation:

1. Xenon Pharmaceuticals Inc., 200-3650 Gilmore Way, Burnaby, British Columbia V5G 4W8, Canada

2. RJD Medicinal Chemistry and Drug Discovery Consulting LLC, Westfield, New Jersey 07090, United States

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.9b01032

Reference68 articles.

1. New avenues for anti-epileptic drug discovery and development

2. Key factors in the discovery and development of new antiepileptic drugs