Molecular Pharmacology of Selective Na<sub>V</sub>1.6 and Dual Na<sub>V</sub>1.6/Na<sub>V</sub>1.2 Channel Inhibitors that Suppress Excitatory Neuronal Activity Ex Vivo-Reference-Cited by-同舟云学术

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Molecular Pharmacology of Selective Na_V1.6 and Dual Na_V1.6/Na_V1.2 Channel Inhibitors that Suppress Excitatory Neuronal Activity Ex Vivo

Published:2024-02-15 Issue:6 Volume:15 Page:1169-1184
ISSN:1948-7193
Container-title:ACS Chemical Neuroscience
language:en
Short-container-title:ACS Chem. Neurosci.

Author:

Goodchild Samuel J.¹^ORCID,Shuart Noah Gregory¹,Williams Aaron D.¹,Ye Wenlei²,Parrish R. Ryley¹,Soriano Maegan¹,Thouta Samrat¹,Mezeyova Janette¹,Waldbrook Matthew¹,Dean Richard¹,Focken Thilo¹^ORCID,Ghovanloo Mohammad-Reza¹³⁴^ORCID,Ruben Peter C.³,Scott Fiona²,Cohen Charles J.¹,Empfield James¹,Johnson JP¹

Affiliation:

1. Department of Cellular and Molecular Biology, Xenon Pharmaceuticals, Burnaby, BC V5G 4W8, Canada

2. Neurocrine Biosciences, San Diego, California 92130, United States

3. Department of Biomedical Physiology and Kinesiology, Simon Fraser University, Burnaby, BC V5A 1S6, Canada

4. Department of Neurology, Yale University, New Haven, Connecticut 06519, United States

Funder

Natural Sciences and Engineering Research Council of Canada

Mitacs

Xenon Pharmaceuticals, Inc.

Publisher

American Chemical Society (ACS)

Link

https://pubs.acs.org/doi/pdf/10.1021/acschemneuro.3c00757

Reference54 articles.

1. The action potential in mammalian central neurons

2. A quantitative description of membrane current and its application to conduction and excitation in nerve

3. NBI-921352, a first-in-class, NaV1.6 selective, sodium channel inhibitor that prevents seizures in Scn8a gain-of-function mice, and wild-type mice and rats

4. Localization of Voltage-Gated Ion Channels IN Mammalian Brain

Cited by 2 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Brain Chimeroids reveal individual susceptibility to neurotoxic triggers;Nature;2024-06-26

2. The contribution of Na_V1.6 to the efficacy of voltage‐gated sodium channel inhibitors in wild type and Na_V1.6 gain‐of‐function (GOF) mouse seizure control;British Journal of Pharmacology;2024-06-24

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