Chemical Space Exploration around Thieno[3,2-d]pyrimidin-4(3H)-one Scaffold Led to a Novel Class of Highly Active Clostridium difficile Inhibitors-Reference-Cited by-同舟云学术

Chemical Space Exploration around Thieno[3,2-d]pyrimidin-4(3H)-one Scaffold Led to a Novel Class of Highly Active Clostridium difficile Inhibitors

Published:2019-10-04 Issue:21 Volume:62 Page:9772-9791
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Shao Xuwei¹,AbdelKhalek Ahmed²,Abutaleb Nader S.²^ORCID,Velagapudi Uday Kiran¹,Yoganathan Sabesan¹^ORCID,Seleem Mohamed N.²³^ORCID,Talele Tanaji T.¹^ORCID

Affiliation:

1. Department of Pharmaceutical Sciences, College of Pharmacy and Health Sciences, St. John’s University, Queens, New York 11439-0001, United States

2. Department of Comparative Pathobiology, Purdue University College of Veterinary Medicine, West Lafayette, Indiana 47907-2027, United States

3. Purdue Institute of Inflammation, Immunology, and Infectious Disease, West Lafayette, Indiana 47907-2027, United States

Funder

National Institute of Allergy and Infectious Diseases

Department of Pharmaceutical Sciences, St. John?s University

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.9b01198

Reference61 articles.

1. Clostridium difficile colitis causing toxic megacolon, severe sepsis and multiple organ dysfunction syndrome

2. Clostridium difficile–Associated Diarrhea

3. Guidelines for Diagnosis, Treatment, and Prevention of Clostridium difficile Infections

4. The Pervasive Effects of an Antibiotic on the Human Gut Microbiota, as Revealed by Deep 16S rRNA Sequencing

5. An Epidemic, Toxin Gene–Variant Strain ofClostridium difficile

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