Design, Synthesis, and Biological Evaluation of Imidazo[1,2-a]pyridine Derivatives as Novel PI3K/mTOR Dual Inhibitors-Reference-Cited by-同舟云学术

Design, Synthesis, and Biological Evaluation of Imidazo[1,2-a]pyridine Derivatives as Novel PI3K/mTOR Dual Inhibitors

Published:2020-02-18 Issue:6 Volume:63 Page:3028-3046
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Yu Ya’nan¹,Han Yuqiao¹,Zhang Fupo¹,Gao Zhenmei¹,Zhu Tong¹,Dong Suzhen¹,Ma Mingliang¹²^ORCID

Affiliation:

1. Shanghai Engineering Research Center of Molecular Therapeutics and New Drug Development, School of Chemistry and Molecular Engineering, East China Normal University, Shanghai 200062, P. R. China

2. Key Laboratory of Brain Functional Genomics, Ministry of Education, East China Normal University, Shanghai 200062, P. R. China

Funder

National Natural Science Foundation of China

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.9b01736

Reference23 articles.

1. PI3K and cancer: lessons, challenges and opportunities

2. Phosphorylation and Regulation of Akt/PKB by the Rictor-mTOR Complex

3. The phosphatidylinositol 3-Kinase–AKT pathway in human cancer

4. PI3K-Akt pathway: Its functions and alterations in human cancer

5. PI3K in cancer: divergent roles of isoforms, modes of activation and therapeutic targeting

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