Hip To Be Square: Oxetanes as Design Elements To Alter Metabolic Pathways-Reference-Cited by-同舟云学术

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Hip To Be Square: Oxetanes as Design Elements To Alter Metabolic Pathways

Published:2019-07-16 Issue:16 Volume:62 Page:7383-7399
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Toselli Francesca¹,Fredenwall Marlene¹,Svensson Peder²,Li Xue-Qing¹,Johansson Anders¹^ORCID,Weidolf Lars¹,Hayes Martin A.³^ORCID

Affiliation:

1. Research and Early Development, Cardiovascular, Renal and Metabolism, BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden

2. Integrative Research Laboratories, Arvid Wallgrens Backe 20, Gothenburg 413 46, Sweden

3. Discovery Sciences, BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.9b00030

Reference42 articles.

1. Survey of Human Oxidoreductases and Cytochrome P450 Enzymes Involved in the Metabolism of Xenobiotic and Natural Chemicals

2. Cytochrome P450 enzymes in drug metabolism: Regulation of gene expression, enzyme activities, and impact of genetic variation

3. The role of aldehyde oxidase in drug metabolism

4. Significance of aldehyde oxidase during drug development: Effects on drug metabolism, pharmacokinetics, toxicity, and efficacy

5. Strategies for a comprehensive understanding of metabolism by aldehyde oxidase

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1. Advances in targeting Phosphodiesterase 1: From mechanisms to potential therapeutics;European Journal of Medicinal Chemistry;2024-01

2. Phosphine-catalyzed enantioselective and diastereodivergent [3+2] cyclization for the construction of oxetane dispirooxindole skeletons;Chemical Communications;2024

3. Recent advances in the synthesis of 3,3-disubstituted oxetanes;Advances in Heterocyclic Chemistry;2024

4. Applications of oxetanes in drug discovery and medicinal chemistry;European Journal of Medicinal Chemistry;2023-12

5. Oxetanes in Drug Discovery Campaigns;Journal of Medicinal Chemistry;2023-09-07

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