DNA-Encoded Library Technology-Based Discovery, Lead Optimization, and Prodrug Strategy toward Structurally Unique Indoleamine 2,3-Dioxygenase-1 (IDO1) Inhibitors-Reference-Cited by-同舟云学术

DNA-Encoded Library Technology-Based Discovery, Lead Optimization, and Prodrug Strategy toward Structurally Unique Indoleamine 2,3-Dioxygenase-1 (IDO1) Inhibitors

Published:2020-02-19 Issue:7 Volume:63 Page:3552-3562
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Kazmierski Wieslaw M.¹^ORCID,Xia Bing²,Miller John¹,De la Rosa Martha¹,Favre David¹,Dunham Richard M.¹,Washio Yoshiaki³,Zhu Zhengrong²^ORCID,Wang Feng⁴,Mebrahtu Makda⁵,Deng Hongfeng²,Basilla Jonathan⁵,Wang Liping⁶,Evindar Ghotas²,Fan Lijun²,Olszewski Alison²,Prabhu Ninad²,Davie Christopher²,Messer Jeffrey A.²^ORCID,Samano Vicente¹

Affiliation:

1. HIV Discovery Performance Unit, GlaxoSmithKline, Research Triangle Park, Durham, North Carolina 27709, United States

2. Encoded Library Technologies/NCE Molecular Discovery, R&D Medicinal Science and Technology, GSK, 200 Cambridge Park Drive, Cambridge, Massachusetts 02140, United States

3. MST Medicine Design, Medicinal Chemistry, GlaxoSmithKline, Gunnels Wood Rd, Stevenage SG1 2NY, U.K.

4. DMPK/IVIVT, GlaxoSmithKline, 1250 S. Collegeville Rd, Collegeville, Pennsylvania 19426-0989, United States

5. Screening, Profiling & Mechanistic Biology, RD Platform Technology & Science, GlaxoSmithKline, 1250 S. Collegeville Rd, Collegeville, Pennsylvania 19426-0989, United States

6. Drug Design and Selection, GlaxoSmithKline, 1250 S. Collegeville Rd, Collegeville, Pennsylvania 19426, United States

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.9b01799

Reference38 articles.

1. Kynurenine Pathway of Tryptophan Metabolism: Regulatory and Functional Aspects

2. Reversal of tumoral immune resistance by inhibition of tryptophan 2,3-dioxygenase

3. Heme-binding-mediated negative regulation of the tryptophan metabolic enzyme indoleamine 2,3-dioxygenase 1 (IDO1) by IDO2

4. IDO2 is critical for IDO1-mediated T-cell regulation and exerts a non-redundant function in inflammation

5. IDO2 in Immunomodulation and Autoimmune Disease

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