Discovery of a New Anti-Inflammatory Agent from Anemoside B4 Derivatives and Its Therapeutic Effect on Colitis by Targeting Pyruvate Carboxylase-Reference-Cited by-同舟云学术

Discovery of a New Anti-Inflammatory Agent from Anemoside B4 Derivatives and Its Therapeutic Effect on Colitis by Targeting Pyruvate Carboxylase

Published:2024-04-30 Issue:9 Volume:67 Page:7385-7405
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Lv Lijuan¹,Li Qiurong¹,Wang Kexin¹,Zhao Jianping²,Deng Kejun³,Zhang Ran¹,Chen Zhong¹,Khan Ikhlas A.²,Gui Chunshan¹^ORCID,Feng Suxiang⁴,Yang Shilin¹,Liu Yanli¹,Xu Qiongming¹^ORCID

Affiliation:

1. College of Pharmaceutical Sciences, Soochow University, Suzhou, Jiangsu 215123, China

2. National Center for Natural Products Research, School of Pharmacy, University of Mississippi, University, Mississippi 38677, United States

3. School of Life Science and Technology, Center for Informational Biology, University of Electronic Science and Technology of China, Chengdu, Sichuan 610054, China

4. Academy of Chinese Medicine Sciences, Henan University of Chinese Medicine, Zhengzhou, Henan 450018, China

Funder

National Natural Science Foundation of China

Priority Academic Program Development of Jiangsu Higher Education Institutions

State Key Laboratory of Natural and Biomimetic Drugs

Publisher

American Chemical Society (ACS)

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.4c00222

Reference56 articles.

1. Inflammatory Bowel Disease Presentation and Diagnosis

2. Inflammatory bowel disease: Pathogenesis

3. A review of the diagnosis, prevention, and treatment methods of inflammatory bowel disease

4. STRIDE-II: An Update on the Selecting Therapeutic Targets in Inflammatory Bowel Disease (STRIDE) Initiative of the International Organization for the Study of IBD (IOIBD): Determining Therapeutic Goals for Treat-to-Target strategies in IBD

5. NF-κB regulation in the immune system

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2. Synthesis and Evaluation of 1,3-Disubstituted Imidazolidine-2,4,5-triones as Inhibitors of Pyruvate Carboxylase;ACS Medicinal Chemistry Letters;2024-06-26