Synthesis and Evaluation of 1,3-Disubstituted Imidazolidine-2,4,5-triones as Inhibitors of Pyruvate Carboxylase-Reference-Cited by-同舟云学术

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Synthesis and Evaluation of 1,3-Disubstituted Imidazolidine-2,4,5-triones as Inhibitors of Pyruvate Carboxylase

Published:2024-06-26 Issue:7 Volume:15 Page:1088-1093
ISSN:1948-5875
Container-title:ACS Medicinal Chemistry Letters
language:en
Short-container-title:ACS Med. Chem. Lett.

Author:

Schneider Nicholas O.¹,Gilreath Kendra²,Henriksen Niel M.³,Donaldson William A.²^ORCID,Chaudhury Subhabrata²^ORCID,St. Maurice Martin¹^ORCID

Affiliation:

1. Department of Biological Science, Marquette University, P.O. Box 1881, Milwaukee, Wisconsin 53201-1881, United States

2. Department of Chemistry, Marquette University, P.O. Box 1881, Milwaukee, Wisconsin 53201-1881, United States

3. Atomwise, Inc., 250 Sutter St, Suite 650, San Francisco, California 94108, United States

Funder

National Institute of General Medical Sciences

Publisher

American Chemical Society (ACS)

Link

https://pubs.acs.org/doi/pdf/10.1021/acsmedchemlett.4c00183

Reference38 articles.

1. Pyruvate carboxylase is critical for non–small-cell lung cancer proliferation

2. Pyruvate Carboxylase Is Up-Regulated in Breast Cancer and Essential to Support Growth and Invasion of MDA-MB-231 Cells

3. Mass spectrometry analysis shows the biosynthetic pathways supported by pyruvate carboxylase in highly invasive breast cancer cells

4. Integrated analysis of transcriptomic and metabolomic data demonstrates the significant role of pyruvate carboxylase in the progression of ovarian cancer

5. Pyruvate carboxylase promotes malignant transformation of papillary thyroid carcinoma and reduces iodine uptake

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