Complex Target-Oriented Total Synthesis in the Drug Discovery Process: The Discovery of a Highly Promising Family of Second Generation Epothilones-Reference-Cited by-同舟云学术

Complex Target-Oriented Total Synthesis in the Drug Discovery Process: The Discovery of a Highly Promising Family of Second Generation Epothilones

Published:2003-02-06 Issue:10 Volume:125 Page:2899-2901
ISSN:0002-7863
Container-title:Journal of the American Chemical Society
language:en
Short-container-title:J. Am. Chem. Soc.

Author:

Rivkin Alexey¹,Yoshimura Fumihiko¹,Gabarda Ana E.¹,Chou Ting-Chao¹,Dong Huajin¹,Tong William P.¹,Danishefsky Samuel J.¹

Affiliation:

1. Laboratory for Bioorganic Chemistry, Preclinical Pharmacology Core Facility, and Analytical Pharmacology Core Facility, Sloan-Kettering Institute for Cancer Research, 1275 York Avenue, New York, New York 10021, and Department of Chemistry, Columbia University, Havemeyer Hall, New York, New York 10027

Publisher

American Chemical Society (ACS)

Subject

Colloid and Surface Chemistry,Biochemistry,General Chemistry,Catalysis

Link

https://pubs.acs.org/doi/pdf/10.1021/ja029695p

Reference16 articles.

1. Complex Target-Oriented Synthesis in the Drug Discovery Process: A Case History in the dEpoB Series

2. The synthesis, discovery, and development of a highly promising class of microtubule stabilization agents: Curative effects of desoxyepothilones B and F against human tumor xenografts in nude mice

3. On the Introduction of a Trifluoromethyl Substituent in the Epothilone Setting: Chemical Issues Related to Ring Forming Olefin Metathesis and Earliest Biological Findings

4. Total Syntheses of [17]- and [18]Dehydrodesoxyepothilones B via a Concise Ring-Closing Metathesis-Based Strategy: Correlation of Ring Size with Biological Activity in the Epothilone Series

5. Total Synthesis of Epothilone B, Epothilone D, and cis- and trans-9,10-Dehydroepothilone D

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