On the Introduction of a Trifluoromethyl Substituent in the Epothilone Setting: Chemical Issues Related to Ring Forming Olefin Metathesis and Earliest Biological Findings-Reference-Cited by-同舟云学术

On the Introduction of a Trifluoromethyl Substituent in the Epothilone Setting: Chemical Issues Related to Ring Forming Olefin Metathesis and Earliest Biological Findings

Published:2002-10-17 Issue:23 Volume:4 Page:4081-4084
ISSN:1523-7060
Container-title:Organic Letters
language:en
Short-container-title:Org. Lett.

Author:

Rivkin Alexey¹,Biswas Kaustav¹,Chou Ting-Chao¹,Danishefsky Samuel J.¹

Affiliation:

1. Laboratories for Bioorganic Chemistry, Sloan-Kettering Institute for Cancer Research, 1275 York Avenue, New York, New York 10021, and Department of Chemistry, Columbia University, Havemeyer Hall, New York, New York 10027

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/ol0268283

Reference14 articles.

1. Complex Target-Oriented Synthesis in the Drug Discovery Process: A Case History in the dEpoB Series

2. The synthesis, discovery, and development of a highly promising class of microtubule stabilization agents: Curative effects of desoxyepothilones B and F against human tumor xenografts in nude mice

3. Epothilones and their analogues - a new class of promising microtubule inhibitors

4. Desoxyepothilone B is curative against human tumor xenografts that are refractory to paclitaxel

5. Desoxyepothilone B: An efficacious microtubule-targeted antitumor agent with a promising in vivo profile relative to epothilone B

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