2-Nitrophenylcarbamoyl-(S)-prolyl-(S)-3-(2-naphthyl)alanyl-N-benzyl-N- methylamide (SDZ NKT 343), a Potent Human NK1 Tachykinin Receptor Antagonist with Good Oral Analgesic Activity in Chronic Pain Models-Reference-Cited by-同舟云学术

2-Nitrophenylcarbamoyl-(S)-prolyl-(S)-3-(2-naphthyl)alanyl-N-benzyl-N- methylamide (SDZ NKT 343), a Potent Human NK1 Tachykinin Receptor Antagonist with Good Oral Analgesic Activity in Chronic Pain Models

Published:1998-07-21 Issue:17 Volume:41 Page:3159-3173
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Walpole C.¹,Ko S. Y.¹,Brown M.¹,Beattie D.¹,Campbell E.¹,Dickenson F.¹,Ewan S.¹,Hughes G. A.¹,Lemaire M.¹,Lerpiniere J.¹,Patel S.¹,Urban L.¹

Affiliation:

1. Novartis Institute for Medical Sciences, 5 Gower Place, London WC1E 6BN, U.K.

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm970499g

Reference36 articles.

1. Mammalian Tachykinin Receptors

2. A Potent Nonpeptide Antagonist of the Substance P (NK 1 ) Receptor

3. Pharmacological properties of a potent and selective nonpeptide substance P antagonist.

4. Studies on Neurokinin Antagonists. 4. Synthesis and Structure-Activity Relationships of Novel Dipeptide Substance P Antagonists: N2-[(4R)-4-Hydroxy-1-[(1-methyl-1H-indol-3-yl)carbonyl]-L-prolyl]-N-methyl-N-(phenylmethyl)-3-(2-naphthyl)-L-alaninamide and Its Related Compounds

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