Exploration of the Pharmacophore of 3-Alkyl-5-Arylimidazolidinediones as New CB1 Cannabinoid Receptor Ligands and Potential Antagonists: Synthesis, Lipophilicity, Affinity, and Molecular Modeling-Reference-Cited by-同舟云学术

Exploration of the Pharmacophore of 3-Alkyl-5-Arylimidazolidinediones as New CB1 Cannabinoid Receptor Ligands and Potential Antagonists: Synthesis, Lipophilicity, Affinity, and Molecular Modeling

Published:2002-03-26 Issue:9 Volume:45 Page:1748-1756
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Ooms Frédéric¹,Wouters Johan¹,Oscari Olivier¹,Happaerts Thierry¹,Bouchard Géraldine¹,Carrupt Pierre-Alain¹,Testa Bernard¹,Lambert Didier M.¹

Affiliation:

1. Institut de Chimie Thérapeutique, Ecole de Pharmacie, Université de Lausanne, CH-1015 Lausanne, Switzerland, Laboratoire de Chimie Moléculaire Structurale, Faculté des Sciences, Facultés universitaires Notre Dame de la Paix, Rue de Bruxelles 61, B-5000 Namur, Belgium, and Unité de Chimie pharmaceutique et de Radiopharmacie, Ecole de Pharmacie, Faculté de Médecine, Université catholique de Louvain, Avenue E. Mounier 73 UCL-CMFA 7340, B-1200 Bruxelles, Belgium

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm010896y

Reference36 articles.

1. Isolation, Structure, and Partial Synthesis of an Active Constituent of Hashish

2. Molecular probes for the cannabinoid receptors

3. Structure of a cannabinoid receptor and functional expression of the cloned cDNA

4. Molecular cloning of a human cannabinoid receptor which is also expressed in testis

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