Identifying the structural features and diversifying the chemical domain of peripherally acting CB1 receptor antagonists using molecular modeling techniques-Reference-Cited by-同舟云学术

Identifying the structural features and diversifying the chemical domain of peripherally acting CB1 receptor antagonists using molecular modeling techniques

Published:2016 Issue:2 Volume:6 Page:1466-1483
ISSN:2046-2069
Container-title:RSC Advances
language:en
Short-container-title:RSC Adv.

Author:

Sharma Mayank Kumar¹²³⁴,Murumkar Prashant R.¹²³⁴,Kuang Guanglin⁵⁶⁷⁸⁹,Tang Yun⁵⁶⁷⁸⁹,Yadav Mange Ram¹²³⁴

Affiliation:

1. Faculty of Pharmacy

2. The M. S. University of Baroda

3. Vadodara–390 001

4. India

5. Shanghai Key Laboratory of New Drug Design

6. School of Pharmacy

7. East China University of Science and Technology

8. Shanghai–200237

9. China

Abstract

A four featured pharmacophore and predictive 3D-QSAR models were developed which were used for virtual screening of the Asinex database to get chemically diverse hits of peripherally active CB1 receptor antagonists.

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2016/RA/C5RA20612J

Reference78 articles.

1. CB1 antagonists for obesity—what lessons have we learned from rimonabant?

2. Obesity, a health burden of a global nature

3. Novel antiobesity agents: Synthesis and pharmacological evaluation of analogues of Rimonabant and of LH21

4. Prospective therapeutic agents for obesity: Molecular modification approaches of centrally and peripherally acting selective cannabinoid 1 receptor antagonists

5. http://www.who.int/mediacentre/factsheets/fs311/en/index.html, accessed 14 July 2014

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