Identifying the structural features and diversifying the chemical domain of peripherally acting CB1 receptor antagonists using molecular modeling techniques
Author:
Affiliation:
1. Faculty of Pharmacy
2. The M. S. University of Baroda
3. Vadodara–390 001
4. India
5. Shanghai Key Laboratory of New Drug Design
6. School of Pharmacy
7. East China University of Science and Technology
8. Shanghai–200237
9. China
Abstract
A four featured pharmacophore and predictive 3D-QSAR models were developed which were used for virtual screening of the Asinex database to get chemically diverse hits of peripherally active CB1 receptor antagonists.
Publisher
Royal Society of Chemistry (RSC)
Subject
General Chemical Engineering,General Chemistry
Link
http://pubs.rsc.org/en/content/articlepdf/2016/RA/C5RA20612J
Reference78 articles.
1. CB1 antagonists for obesity—what lessons have we learned from rimonabant?
2. Obesity, a health burden of a global nature
3. Novel antiobesity agents: Synthesis and pharmacological evaluation of analogues of Rimonabant and of LH21
4. Prospective therapeutic agents for obesity: Molecular modification approaches of centrally and peripherally acting selective cannabinoid 1 receptor antagonists
5. http://www.who.int/mediacentre/factsheets/fs311/en/index.html, accessed 14 July 2014
Cited by 9 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献
1. In Silico Approach for Developing New Anti-Tuberculosis Drug Candidates: 3D-QSAR, Molecular Docking and ADME Studies of Pretomanid Derivatives;PHYS CHEM RES;2024
2. Structure-guided Design and Optimization of small Molecules as Pancreatic Lipase Inhibitors using Pharmacophore, 3D-QSAR, Molecular Docking, and Molecular Dynamics Simulation Studies;Current Computer-Aided Drug Design;2023-08
3. Molecular Modeling and Docking Studies of 2,4,5-Trisubstituted Pyrimidines as HIV-1 Non-Nucleoside Reverse Transcriptase Inhibitors;Polycyclic Aromatic Compounds;2022-11-13
4. Pharmacophore-based virtual screening from phytocannabinoids as antagonist r-CB1;Journal of Molecular Modeling;2022-08-17
5. Identification of Hydroxamic Acid Based Selective HDAC1 Inhibitors: Computer Aided Drug Design Studies;Current Computer-Aided Drug Design;2019-03-12
1.学者识别学者识别
2.学术分析学术分析
3.人才评估人才评估
"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370
www.globalauthorid.com
TOP
Copyright © 2019-2024 北京同舟云网络信息技术有限公司 京公网安备11010802033243号 京ICP备18003416号-3