Discovery of a 2,4-Diamino-7-aminoalkoxyquinazoline as a Potent and Selective Inhibitor of Histone Lysine Methyltransferase G9a-Reference-Cited by-同舟云学术

Discovery of a 2,4-Diamino-7-aminoalkoxyquinazoline as a Potent and Selective Inhibitor of Histone Lysine Methyltransferase G9a

Published:2009-11-05 Issue:24 Volume:52 Page:7950-7953
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Liu Feng¹,Chen Xin¹,Allali-Hassani Abdellah²,Quinn Amy M.³,Wasney Gregory A.²,Dong Aiping²,Barsyte Dalia²,Kozieradzki Ivona²,Senisterra Guillermo²,Chau Irene²,Siarheyeva Alena²,Kireev Dmitri B.¹,Jadhav Ajit³,Herold J. Martin¹,Frye Stephen V.¹,Arrowsmith Cheryl H.²,Brown Peter J.²,Simeonov Anton³,Vedadi Masoud²,Jin Jian¹

Affiliation:

1. Center for Integrated Chemical Biology and Drug Discovery, Division of Medicinal Chemistry and Natural Products, Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599

2. Structural Genomics Consortium, University of Toronto, Toronto, Ontario, M5G 1L6, Canada

3. NIH Chemical Genomics Center, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland 20892

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm901543m

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