Synthesis and Preliminary Studies of a Novel Negative Allosteric Modulator, 7-((2,5-Dioxopyrrolidin-1-yl)methyl)-4-(2-fluoro-4-[11C]methoxyphenyl) quinoline-2-carboxamide, for Imaging of Metabotropic Glutamate Receptor 2

Author:

Zhang Xiaofei123,Kumata Katsushi4,Yamasaki Tomoteru4,Cheng Ran12,Hatori Akiko4,Ma Longle12,Zhang Yiding4,Xie Lin4,Wang Lu12,Kang Hye Jin5,Sheffler Douglas J.6,Cosford Nicholas D. P.6,Zhang Ming-Rong4ORCID,Liang Steven H.12ORCID

Affiliation:

1. Nuclear Medicine and Molecular Imaging, Massachusetts General Hospital, Boston, Massachusetts 02114, United States

2. Department of Radiology, Harvard Medical School, Boston, Massachusetts 02114, United States

3. State Key Laboratory and Institute of Elemento-Organic Chemistry, Collaborative Innovation Center of Chemical Science and Engineering, Nankai Unviersity, Tianjin 300071, China

4. Department of Radiopharmaceutics Development, National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology, Chiba 263-8555, Japan

5. Department of Pharmacology & National Institute of Mental Health Psychoactive Drug Screening Program, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27515, United States

6. Cancer Metabolism and Signaling Networks Program and Conrad Prebys Center for Chemical Genomics, Sanford-Burnham Prebys Medical Discovery Institute, La Jolla, California 92037, United States

Funder

National Institute on Drug Abuse

China Scholarship Council

National Institute of Mental Health

Publisher

American Chemical Society (ACS)

Subject

Cell Biology,Cognitive Neuroscience,Physiology,Biochemistry,General Medicine

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