Synthesis of Ellipticine: A Radical Cascade Protocol to Aryl- and Heteroaryl-Annulated[b]carbazoles-Reference-Cited by-同舟云学术

Synthesis of Ellipticine: A Radical Cascade Protocol to Aryl- and Heteroaryl-Annulated[b]carbazoles

Published:2005-11-16 Issue:25 Volume:70 Page:10615-10618
ISSN:0022-3263
Container-title:The Journal of Organic Chemistry
language:en
Short-container-title:J. Org. Chem.

Author:

Pedersen Jan M.¹,Bowman W. Russell¹,Elsegood Mark R. J.¹,Fletcher Anthony J.¹,Lovell Peter J.¹

Affiliation:

1. Department of Chemistry, Loughborough University, Loughborough, Leics. LE11 3TU, Great Britain, and Psychiatry Medicinal Chemistry III, GlaxoSmithKline, New Frontiers Science Park North, Harlow, Essex CM19 5AW, Great Britain %w.r.bowman@lboro.ac.uk

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/jo0519920

Reference29 articles.

1. Alkaloids of Lunasia amara Blanco. Structure of Lunacrine

2. The anticancer agent ellipticine on activation by cytochrome P450 forms covalent DNA adducts☆1☆Supported by German Cancer Research Center, Grant Agency of the Czech Republic (grant 203/01/0996) and the Ministry of Education of the Czech Republic (grant MSM 1131 00001).1Abbreviations: α-NF, α-naphthoflavone; 3-IPMDIA, 3-isopropenyl-3-methyldiamantane; CHAPS, 3-[(3-cholamidopropyl)-dimethylammonio]-1-propane sulfonate; CYP, cytochrome P450; IC50, 50% inhibitory dose; MDR, multidrug resistance; PEI, polyethylenimine; RAL, relative adduct labeling; TLC, thin-layer chromatography

3. DNA adduct formation by the anticancer drug ellipticine in rats determined by32P postlabeling

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