Synthesis and evaluation of potent (iso)ellipticine-based inhibitors of MYLK4 accessed via expeditious synthesis from isoquinolin-5-ol

Author:

Lee Szu1,Chao Min-Wu234,Wu Yi-Wen5,Hsu Chia-Min5,Lin Tony Eight56,Hsu Kai-Cheng56789,Pan Shiow-Lin56789,Lee Hsueh-Yun1910ORCID

Affiliation:

1. School of Pharmacy, College of Pharmacy, Taipei Medical University, Taiwan

2. School of Medicine, College of Medicine, National Sun Yat-sen University, Kaohsiung, Taiwan

3. Institute of Biopharmaceutical Sciences, College of Medicine, National Sun Yat-sen University, Kaohsiung, Taiwan

4. The Doctoral Program of Clinical and Experimental Medicine, College of Medicine, National Sun Yat-sen University, Kaohsiung, Taiwan

5. Graduate Institute of Cancer Biology and Drug Discovery, College of Medical Science and Technology, Taipei Medical University, Taipei, Taiwan

6. PhD Program for Cancer Molecular Biology and Drug Discovery, College of Medical Science and Technology, Taipei Medical University, Taipei, Taiwan

7. TMU Research Center of Cancer Translational Medicine, Taipei Medical University, Taipei, Taiwan

8. TMU Research Center for Drug Discovery, Taipei Medical University, Taipei, Taiwan

9. PhD Program in Drug Discovery and Development Industry, College of Pharmacy, Taipei Medical University, Taipei, Taiwan

10. Master Program in Clinical Genomics and Proteomics, College of Pharmacy, Taipei Medical University, Taipei, Taiwan

Abstract

The K2S2O8-mediated generation of p-iminoquinone contributed to the regioselective substitution of isoquinolin-5,8-dione.

Funder

National Science and Technology Council

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

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