Quantum Mechanics/Molecular Mechanics Modeling of Fatty Acid Amide Hydrolase Reactivation Distinguishes Substrate from Irreversible Covalent Inhibitors-Reference-Cited by-同舟云学术

Quantum Mechanics/Molecular Mechanics Modeling of Fatty Acid Amide Hydrolase Reactivation Distinguishes Substrate from Irreversible Covalent Inhibitors

Published:2013-03-07 Issue:6 Volume:56 Page:2500-2512
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Lodola Alessio¹,Capoferri Luigi¹,Rivara Silvia¹,Tarzia Giorgio²,Piomelli Daniele³⁴,Mulholland Adrian⁵,Mor Marco¹

Affiliation:

1. Dipartimento di Farmacia, Università degli Studi di Parma, I-43124 Parma, Italy

2. Dipartimento di Scienze Biomolecolari, Università degli Studi di Urbino “Carlo Bo”, I-61029, Urbino, Italy

3. Department of Drug Discovery and Development, Istituto Italiano di Tecnologia, I-16163 Genova, Italy

4. Department of Anatomy and Neurobiology, University of California, Irvine, California 92697, United States

5. School of Chemistry, University of Bristol, Bristol BS8 1TS, U.K.

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm301867x

Reference70 articles.

1. The molecular logic of endocannabinoid signalling

2. Fatty Acid Amide Hydrolase: From Characterization to Therapeutics

3. Modulation of anxiety through blockade of anandamide hydrolysis

4. Antidepressant-like activity and modulation of brain monoaminergic transmission by blockade of anandamide hydrolysis

5. Analgesic actions of N -arachidonoyl-serotonin, a fatty acid amide hydrolase inhibitor with antagonistic activity at vanilloid TRPV1 receptors

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