Mechanistic Modeling of Monoglyceride Lipase Covalent Modification Elucidates the Role of Leaving Group Expulsion and Discriminates Inhibitors with High and Low Potency
Author:
Affiliation:
1. Dipartimento di Scienze degli Alimenti e del Farmaco, Università degli Studi di Parma, Parco Area delle Scienze 27/A, I-43124 Parma, Italy
2. Microbiome Research Hub, University of Parma, Parco Area delle Scienze 11/A, I-43124 Parma, Italy
Funder
Universit? degli Studi di Parma
Regione Emilia-Romagna
Ministero dell'Istruzione, dell'Universit? e della Ricerca
Publisher
American Chemical Society (ACS)
Subject
Library and Information Sciences,Computer Science Applications,General Chemical Engineering,General Chemistry
Link
https://pubs.acs.org/doi/pdf/10.1021/acs.jcim.2c00140
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1. Monoacylglycerol lipase (MAGL) as a promising therapeutic target
2. The Potential of Inhibitors of Endocannabinoid Metabolism for Drug Development: A Critical Review
3. An endocannabinoid mechanism for stress-induced analgesia
4. Neuroprotective Effects of MAGL (Monoacylglycerol Lipase) Inhibitors in Experimental Ischemic Stroke
5. Crystal Structure of the Human Monoacylglycerol Lipase, a Key Actor in Endocannabinoid Signaling
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