Mechanistic Modeling of Monoglyceride Lipase Covalent Modification Elucidates the Role of Leaving Group Expulsion and Discriminates Inhibitors with High and Low Potency-Reference-Cited by-同舟云学术

Mechanistic Modeling of Monoglyceride Lipase Covalent Modification Elucidates the Role of Leaving Group Expulsion and Discriminates Inhibitors with High and Low Potency

Published:2022-05-17 Issue:11 Volume:62 Page:2771-2787
ISSN:1549-9596
Container-title:Journal of Chemical Information and Modeling
language:en
Short-container-title:J. Chem. Inf. Model.

Author:

Galvani Francesca¹^ORCID,Scalvini Laura¹^ORCID,Rivara Silvia¹^ORCID,Lodola Alessio¹^ORCID,Mor Marco¹²^ORCID

Affiliation:

1. Dipartimento di Scienze degli Alimenti e del Farmaco, Università degli Studi di Parma, Parco Area delle Scienze 27/A, I-43124 Parma, Italy

2. Microbiome Research Hub, University of Parma, Parco Area delle Scienze 11/A, I-43124 Parma, Italy

Funder

Universit? degli Studi di Parma

Regione Emilia-Romagna

Ministero dell'Istruzione, dell'Universit? e della Ricerca

Publisher

American Chemical Society (ACS)

Subject

Library and Information Sciences,Computer Science Applications,General Chemical Engineering,General Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jcim.2c00140

Reference80 articles.

1. Monoacylglycerol lipase (MAGL) as a promising therapeutic target

2. The Potential of Inhibitors of Endocannabinoid Metabolism for Drug Development: A Critical Review

3. An endocannabinoid mechanism for stress-induced analgesia

4. Neuroprotective Effects of MAGL (Monoacylglycerol Lipase) Inhibitors in Experimental Ischemic Stroke

5. Crystal Structure of the Human Monoacylglycerol Lipase, a Key Actor in Endocannabinoid Signaling

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