Deciphering the Mechanism of Binding Selectivity of Chlorofluoroacetamide-Based Covalent Inhibitors toward L858R/T790M Resistance Mutation-Reference-Cited by-同舟云学术

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Deciphering the Mechanism of Binding Selectivity of Chlorofluoroacetamide-Based Covalent Inhibitors toward L858R/T790M Resistance Mutation

Published:2022-02-04 Issue:4 Volume:62 Page:997-1013
ISSN:1549-9596
Container-title:Journal of Chemical Information and Modeling
language:en
Short-container-title:J. Chem. Inf. Model.

Author:

Akher Farideh Badichi¹²³^ORCID,Farrokhzadeh Abdolkarim²^ORCID,Ravenscroft Neil²,Kuttel Michelle M.¹^ORCID

Affiliation:

1. Department of Computer Science, University of Cape Town, Cape Town 7700, South Africa

2. Department of Chemistry, University of Cape Town, Cape Town 7700, South Africa

3. Department of Biochemistry & Molecular Biology, University of Dalhousie, Halifax, NS B3H 4R2, Canada

Publisher

American Chemical Society (ACS)

Subject

Library and Information Sciences,Computer Science Applications,General Chemical Engineering,General Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jcim.1c01399

Reference100 articles.

1. Epidermal Growth Factor Receptor in Non–Small-Cell Lung Carcinomas: Correlation Between Gene Copy Number and Protein Expression and Impact on Prognosis

2. Mechanistic Study of Potent Fluorinated EGFR Kinase Inhibitors with a Quinazoline Scaffold against L858R/T790M/C797S Resistance Mutation: Unveiling the Fluorine Substituent Cooperativity Effect on the Inhibitory Activity

3. A Mechanistic Study of a Potent and Selective Epidermal Growth Factor Receptor Inhibitor against the L858R/T790M Resistance Mutation

4. EGFR exon mutation distribution and outcome in non-small-cell lung cancer: a Portuguese retrospective study

5. Epidermal growth factor receptor mutations in lung cancer

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2. The switch states of the GDP-bound HRAS affected by point mutations: a study from Gaussian accelerated molecular dynamics simulations and free energy landscapes;Journal of Biomolecular Structure and Dynamics;2023-05-22

3. Deciphering Selectivity Mechanism of BRD9 and TAF1(2) toward Inhibitors Based on Multiple Short Molecular Dynamics Simulations and MM-GBSA Calculations;Molecules;2023-03-12

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