A Mechanistic Study of a Potent and Selective Epidermal Growth Factor Receptor Inhibitor against the L858R/T790M Resistance Mutation-Reference-Cited by-同舟云学术

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A Mechanistic Study of a Potent and Selective Epidermal Growth Factor Receptor Inhibitor against the L858R/T790M Resistance Mutation

Published:2019-10-07 Issue:41 Volume:58 Page:4246-4259
ISSN:0006-2960
Container-title:Biochemistry
language:en
Short-container-title:Biochemistry

Author:

Akher Farideh Badichi¹²^ORCID,Farrokhzadeh Abdolkarim³,Ravenscroft Neil²,Kuttel Michelle M.¹

Affiliation:

1. Department of Computer Science, University of Cape Town, Cape Town 7701, South Africa

2. Department of Chemistry, University of Cape Town, Cape Town 7701, South Africa

3. School of Chemistry and Physics, University of KwaZulu-Natal, Private Bag X01, Pietermaritzburg 3209, South Africa

Publisher

American Chemical Society (ACS)

Subject

Biochemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.biochem.9b00710

Reference81 articles.

1. Design, Synthesis, and Biological Evaluation of Pyrimido[4,5-d]pyrimidine-2,4(1H,3H)-diones as Potent and Selective Epidermal Growth Factor Receptor (EGFR) Inhibitors against L858R/T790M Resistance Mutation

2. Discovery of 1-{(3R,4R)-3-[({5-Chloro-2-[(1-methyl-1H-pyrazol-4-yl)amino]-7H-pyrrolo[2,3-d]pyrimidin-4-yl}oxy)methyl]-4-methoxypyrrolidin-1-yl}prop-2-en-1-one (PF-06459988), a Potent, WT Sparing, Irreversible Inhibitor of T790M-Containing EGFR Mutants

3. Cancer statistics, 2011

4. Challenges and Perspectives on the Development of Small-Molecule EGFR Inhibitors against T790M-Mediated Resistance in Non-Small-Cell Lung Cancer

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1. Structural Insights into the Binding Mode of a BLU-945 Analog with Wild-Type and Mutant EGFRs;Journal of Computational Biophysics and Chemistry;2024-03-16

2. Deciphering the Mechanism of Binding Selectivity of Chlorofluoroacetamide-Based Covalent Inhibitors toward L858R/T790M Resistance Mutation;Journal of Chemical Information and Modeling;2022-02-04

3. Molecular Mechanism Exploration of Potent Fluorinated PI3K Inhibitors with a Triazine Scaffold: Unveiling the Unusual Synergistic Effect of Pyridine-to-Pyrimidine Ring Interconversion and CF3 Defluorination;The Journal of Physical Chemistry B;2021-09-02

4. Impact of HEC72702 chirality on the selective inhibition of hepatitis B virus capsid dimer: A dynamics–structure–energetics perspective;Chemical Biology & Drug Design;2020-08-26

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