Design, Synthesis, and Biological Evaluation of Pyrimido[4,5-d]pyrimidine-2,4(1H,3H)-diones as Potent and Selective Epidermal Growth Factor Receptor (EGFR) Inhibitors against L858R/T790M Resistance Mutation-Reference-Cited by-同舟云学术

Design, Synthesis, and Biological Evaluation of Pyrimido[4,5-d]pyrimidine-2,4(1H,3H)-diones as Potent and Selective Epidermal Growth Factor Receptor (EGFR) Inhibitors against L858R/T790M Resistance Mutation

Published:2018-06-15 Issue:13 Volume:61 Page:5609-5622
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Hao Yongjia¹²,Lyu Jiankun¹,Qu Rong³,Tong Yi¹,Sun Deheng¹,Feng Fang³,Tong Linjiang³,Yang Tingyuan¹,Zhao Zhenjiang¹,Zhu Lili¹,Ding Jian³,Xu Yufang¹,Xie Hua³,Li Honglin¹^ORCID

Affiliation:

1. Shanghai Key Laboratory of New Drug Design, State Key Laboratory of Bioreactor Engineering, School of Pharmacy, East China University of Science and Technology, Shanghai 200237, China

2. School of Pharmacy, Guizhou University of Chinese Medicine, Guiyang 550025, China

3. Division of Anti-tumor Pharmacology, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China

Funder

Ministry of Science and Technology of the People's Republic of China

Science and Technology Commission of Shanghai Municipality

Central Committee of the Communist Party of China

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.8b00346

Reference34 articles.

1. Cancer statistics, 2011