Imidazo[1,2-a]pyridines: Orally Active Positive Allosteric Modulators of the Metabotropic Glutamate 2 Receptor-Reference-Cited by-同舟云学术

Imidazo[1,2-a]pyridines: Orally Active Positive Allosteric Modulators of the Metabotropic Glutamate 2 Receptor

Published:2012-03-01 Issue:6 Volume:55 Page:2688-2701
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Trabanco Andrés A.¹²,Tresadern Gary¹²,Macdonald Gregor J.¹²,Vega Juan Antonio¹²,de Lucas Ana Isabel¹²,Matesanz Encarnación¹²,García Aránzazu¹²,Linares María Lourdes¹²,Alonso de Diego Sergio A.¹²,Alonso José Manuel¹²,Oehlrich Daniel¹²,Ahnaou Abdelah¹²,Drinkenburg Wilhelmus¹²,Mackie Claire¹²,Andrés José Ignacio¹²,Lavreysen Hilde¹²,Cid José María¹²

Affiliation:

1. Neuroscience Medicinal Chemistry and ‡Research Informatics and Integrative Genomics, Janssen Research & Development, Janssen-Cilag S.A., Jarama 75, 45007-Toledo, Spain

2. Neuroscience Medicinal Chemistry, ∥Neuroscience Biology, and ⊥Discovery ADME/Tox, Janssen Research & Development, Turnhoutseweg 30, B-2340, Beerse, Belgium

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm201561r

Reference32 articles.

1. PHARMACOLOGY AND FUNCTIONS OF METABOTROPIC GLUTAMATE RECEPTORS

2. Regulation of Neurotransmitter Release by Metabotropic Glutamate Receptors

3. Distribution of the messenger RNA for a metabotropic glutamate receptor, mGluR2, in the central nervous system of the rat

4. Distribution and abundance of metabotropic glutamate receptor subtype 2 in rat brain revealed by [3H]LY354740 binding in vitro and quantitative radioautography: Correlation with the sites of synthesis, expression, and agonist stimulation of [35S]GTPγs binding

5. Distribution of metabotropic glutamate 2 and 3 receptors in the rat forebrain: Implication in emotional responses and central disinhibition

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