Development of Inhibitors of SAICAR Synthetase (PurC) from <i>Mycobacterium abscessus</i> Using a Fragment-Based Approach-Reference-Cited by-同舟云学术

Development of Inhibitors of SAICAR Synthetase (PurC) from Mycobacterium abscessus Using a Fragment-Based Approach

Published:2022-01-17 Issue:2 Volume:8 Page:296-309
ISSN:2373-8227
Container-title:ACS Infectious Diseases
language:en
Short-container-title:ACS Infect. Dis.

Author:

Charoensutthivarakul Sitthivut¹²^ORCID,Thomas Sherine E.³,Curran Amy¹,Brown Karen P.⁴⁵,Belardinelli Juan M.⁶,Whitehouse Andrew J.¹,Acebrón-García-de-Eulate Marta³^ORCID,Sangan Jaspar⁴⁵,Gramani Subramanian G.¹^ORCID,Jackson Mary⁶^ORCID,Mendes Vitor³^ORCID,Floto R. Andres⁴⁵,Blundell Tom L.³,Coyne Anthony G.¹^ORCID,Abell Chris¹^ORCID

Affiliation:

1. Yusuf Hamied Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, United Kingdom

2. School of Bioinnovation and Bio-based Product Intelligence, Faculty of Science, Mahidol University, Bangkok 10400, Thailand

3. Department of Biochemistry, University of Cambridge, Tennis Court Road, Cambridge CB2 1GA, United Kingdom

4. Molecular Immunity Unit, Department of Medicine, MRC Laboratory of Molecular Biology, University of Cambridge, Francis Crick Avenue, Cambridge Biomedical Campus, Cambridge CB2 0QH, United Kingdom

5. Cambridge Centre for Lung Infection, Royal Papworth Hospital, Cambridge CB23 3RE, United Kingdom

6. Mycobacteria Research Laboratories, Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, Colorado 80523-1682, United States

Funder

American Leprosy Missions

Cystic Fibrosis Trust

Bill and Melinda Gates Foundation

Fondation Botnar

Wellcome Trust

Publisher

American Chemical Society (ACS)

Subject

Infectious Diseases

Link

https://pubs.acs.org/doi/pdf/10.1021/acsinfecdis.1c00432