Scaffold Hopping to Imidazo[1,2-a]pyrazin-8-one Positive Allosteric Modulators of Metabotropic Glutamate 2 Receptor-Reference-Cited by-同舟云学术

Scaffold Hopping to Imidazo[1,2-a]pyrazin-8-one Positive Allosteric Modulators of Metabotropic Glutamate 2 Receptor

Published:2021-08-25 Issue:35 Volume:6 Page:22997-23006
ISSN:2470-1343
Container-title:ACS Omega
language:en
Short-container-title:ACS Omega

Author:

de Lucas Ana I.¹,Vega Juan A.¹,García Molina Aránzazu¹,Linares María Lourdes¹,Tresadern Gary²^ORCID,Lavreysen Hilde³,Oehlrich Daniel⁴^ORCID,Trabanco Andrés A.¹^ORCID,Cid José M.¹^ORCID

Affiliation:

1. Discovery Chemistry, Discovery Sciences, Janssen Research & Development, Division of Janssen-Cilag S.A., Jarama 75A, Toledo 45007, Spain

2. Computational Chemistry, Discovery Sciences, Janssen Research & Development, Division of Janssen Pharmaceutica N.V., Turnhoutseweg 30, B-2340 Beerse, Belgium

3. Clinical Research and Development, Janssen Pharmaceutica N.V., Turnhoutseweg 30, B-2340 Beerse, Belgium

4. Discovery Chemistry, Discovery Sciences, Janssen Research & Development, Division of Janssen Pharmaceutica N.V., Turnhoutseweg 30, B-2340 Beerse, Belgium

Publisher

American Chemical Society (ACS)

Subject

General Chemical Engineering,General Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acsomega.1c03739

Reference28 articles.

1. Ionotropic and metabotropic glutamate receptor structure and pharmacology

2. Evolution, structure, and activation mechanism of family 3/C G-protein-coupled receptors

3. Positive Allosteric Modulators for mGluR2 Receptors: A Medicinal Chemistry Perspective

4. mGluR2 positive allosteric modulators: a patent review (2009 – present)

5. Progress in the Developement of Positive Allosteric Modulators of the Metabotropic Glutamate Receptor 2

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