1. Graduate School of Pharmaceutical Sciences, Nagoya City University, 3-1 Tanabe-dori, Mizuho-ku, Nagoya, Aichi 467-8603, Japan, Graduate School of Bio-Science, Nagahama Institute of Bio-Science Technology, 1266 Tamura-cho, Nagahama, Shiga 526-0829, Japan, and Frontier Pharma Inc., 1281-8 Tamura-cho, Nagahama, Shiga 526-0829, Japan