Synthesis, Evaluation, and Radiolabeling of New Potent Positive Allosteric Modulators of the Metabotropic Glutamate Receptor 2 as Potential Tracers for Positron Emission Tomography Imaging-Reference-Cited by-同舟云学术

Synthesis, Evaluation, and Radiolabeling of New Potent Positive Allosteric Modulators of the Metabotropic Glutamate Receptor 2 as Potential Tracers for Positron Emission Tomography Imaging

Published:2012-10-11 Issue:20 Volume:55 Page:8685-8699
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Andrés José-Ignacio¹,Alcázar Jesús¹,Cid José María¹,De Angelis Meri¹,Iturrino Laura¹,Langlois Xavier²,Lavreysen Hilde²,Trabanco Andrés A.¹,Celen Sofie³,Bormans Guy³

Affiliation:

1. Medicinal Chemistry, Janssen Research & Development, Janssen-Cilag S.A., C/Jarama 75, 45007 Toledo, Spain

2. Neuroscience, Janssen Research & Development, Janssen Pharmaceutica N.V., Turnhoutseweg 30, B-2340 Beerse, Belgium

3. Laboratory for Radiopharmacy and IMIR, Faculty of Pharmaceutical Sciences, K.U. Leuven, Herestraat 49, B-3000 Leuven, Belgium

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm300912k

Reference37 articles.

1. PHARMACOLOGY AND FUNCTIONS OF METABOTROPIC GLUTAMATE RECEPTORS

2. Ionotropic and metabotropic glutamate receptor structure and pharmacology

3. Regulation of Neurotransmitter Release by Metabotropic Glutamate Receptors

4. Activation of metabotropic glutamate receptors as a novel approach for the treatment of schizophrenia

5. From Revolution to Evolution: The Glutamate Hypothesis of Schizophrenia and its Implication for Treatment

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