Abstract
Anxiety disorders represent a prevalent group of mental health conditions characterized by patients experiencing excessive worry, fear, and distress. The neurobiological underpinnings of anxiety disorders are complex and involve multiple neurotransmitter systems. One such system is the glutamatergic system, which plays a critical role in anxiety regulation. Over the past few decades, much evidence has been gathered, substantiating the involvement of metabotropic glutamate receptors (mGluRs) in anxiety. Consequently, mGluRs have emerged as promising targets for treating anxiety disorders. This book chapter will provide an overview of the role of mGluRs in anxiety, focusing on their involvement in anxiety-related behaviors and their potential as therapeutic targets.