Identification of Novel, Selective, and Stable Inhibitors of Class II Histone Deacetylases. Validation Studies of the Inhibition of the Enzymatic Activity of HDAC4 by Small Molecules as a Novel Approach for Cancer Therapy-Reference-Cited by-同舟云学术

Identification of Novel, Selective, and Stable Inhibitors of Class II Histone Deacetylases. Validation Studies of the Inhibition of the Enzymatic Activity of HDAC4 by Small Molecules as a Novel Approach for Cancer Therapy

Published:2009-10-16 Issue:21 Volume:52 Page:6782-6789
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Ontoria Jesus M.¹,Altamura Sergio¹,Di Marco Annalise¹,Ferrigno Federica¹,Laufer Ralph¹,Muraglia Ester¹,Palumbi Maria Cecilia¹,Rowley Michael¹,Scarpelli Rita¹,Schultz-Fademrecht Carsten¹,Serafini Sergio¹,Steinkühler Christian¹,Jones Philip¹

Affiliation:

1. Istituto Di Ricerche Di Biologia Molecolare, P. Angeletti SpA (IRBM-MRL, Rome), Via Pontina Km 30,600, I-00040 Pomezia, Italy

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm900555u

Reference38 articles.

1. Histone deacetylase inhibitors and the promise of epigenetic (and more) treatments for cancer

2. Chemistry and Biology of Chromatin Remodeling Agents: State of Art and Future Perspectives of HDAC Inhibitors

3. From Natural Products to Small Molecule Ketone Histone Deacetylase Inhibitors: Development of New Class Specific Agents

4. Class II (IIa)-Selective Histone Deacetylase Inhibitors. 1. Synthesis and Biological Evaluation of Novel (Aryloxopropenyl)pyrrolyl Hydroxyamides

Cited by 52 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Facile synthesis of α-sulfonyl ketoximes from alkenes using sodium sulfinate and NaNO₂ in water;Organic Chemistry Frontiers;2024

2. Synthesis of ¹⁸F-labelled aryl trifluoromethyl ketones with improved molar activity;Chemical Communications;2024

3. The Zinc-Binding Group Effect: Lessons from Non-Hydroxamic Acid Vorinostat Analogs;Journal of Medicinal Chemistry;2023-06-05

4. Synthesis and Characterization of Reversible Covalent HDAC4 Inhibitors;Methods in Molecular Biology;2022-10-19

5. Pharmacophore-based virtual screening of ZINC database, molecular modeling and designing new derivatives as potential HDAC6 inhibitors;Molecular Diversity;2022-10-10