Design, Synthesis, and Pharmacological Evaluation of Monocyclic Pyrimidinones as Novel Inhibitors of PDE5-Reference-Cited by-同舟云学术

Design, Synthesis, and Pharmacological Evaluation of Monocyclic Pyrimidinones as Novel Inhibitors of PDE5

Published:2012-11-19 Issue:23 Volume:55 Page:10540-10550
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Wang Guan¹,Liu Zheng²,Chen Tiantian¹,Wang Zhen¹,Yang Huaiyu¹,Zheng Mingyue¹,Ren Jing¹,Tian Guanghui²,Yang Xiaojun²,Li Li¹,Li Jianfeng¹,Suo Jin¹,Zhang Rongxia¹,Jiang Xiangrui¹,Terrett Nicholas Kenneth²,Shen Jingshan¹,Xu Yechun¹,Jiang Hualiang¹

Affiliation:

1. CAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zuchongzhi Road, Shanghai 201203, China

2. Vitargeta Therapeutics Inc., Plainsboro, New Jersey 08536, United States

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm301159y

Reference31 articles.

1. Tissue expression, distribution, and regulation of PDE5

2. PDE5 Inhibitors: In Vitro and In Vivo Pharmacological Profile

3. Tissue distribution of phosphodiesterase families and the effects of sildenafil on tissue cyclic nucleotides, platelet function, and the contractile responses of trabeculae carneae and aortic rings in vitro

4. Synthesis and Molecular Modeling of Novel Tetrahydro-β-carboline Derivatives with Phosphodiesterase 5 Inhibitory and Anticancer Properties

5. Expression of cGMP-binding cGMP-specific phosphodiesterase (PDE5) in mouse tissues and cell lines using an antibody against the enzyme amino-terminal domain

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