Synthesis and Molecular Modeling of Novel Tetrahydro-β-carboline Derivatives with Phosphodiesterase 5 Inhibitory and Anticancer Properties-Reference-Cited by-同舟云学术

Synthesis and Molecular Modeling of Novel Tetrahydro-β-carboline Derivatives with Phosphodiesterase 5 Inhibitory and Anticancer Properties

Published:2010-12-28 Issue:2 Volume:54 Page:495-509
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Mohamed Heba A.¹,Girgis Nancy M. R.¹,Wilcken Rainer²,Bauer Matthias R.²,Tinsley Heather N.³,Gary Bernard D.³,Piazza Gary A.³,Boeckler Frank M.²,Abadi Ashraf H.¹

Affiliation:

1. Department of Pharmaceutical Chemistry, Faculty of Pharmacy and Biotechnology, German University in Cairo, Cairo 11835, Egypt

2. Laboratory for Molecular Design and Pharmaceutical Biophysics, Department of Pharmaceutical and Medicinal Chemistry, Institute of Pharmacy, Eberhard-Karls-University, Tübingen, Auf der Morgenstelle 8, 72076 Tübingen, Germany

3. Division of Drug Discovery, Department of Biochemistry and Molecular Biology, Southern Research Institute, The University of Alabama at Birmingham, 2000 Ninth Avenue South, Birmingham, Alabama 35205, United States

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm100842v

Reference24 articles.

1. Biochemistry and Physiology of Cyclic Nucleotide Phosphodiesterases: Essential Components in Cyclic Nucleotide Signaling

2. Overview of PDEs and Their Regulation

3. Sildenafil: from angina to erectile dysfunction to pulmonary hypertension and beyond

4. PDE-5 Inhibitors: Current Status and Future Trends

5. Sildenafil for primary and secondary pulmonary hypertension

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