Recent Advances on the Synthesis and Application of Tetrahydro‐β‐Carbolines

Author:

Du Youlong1,Semghouli Anas2,Mei Haibo1,Kiss Loránd2ORCID,Han Jianlin1ORCID

Affiliation:

1. Jiangsu Co-Innovation Center of Efficient Processing and Utilization of Forest Resources College of Chemical Engineering Nanjing Forestry University Nanjing 210037 People's Republic of China

2. Institute of Organic Chemistry Stereochemistry Research Group HUN-REN Research Centre for Natural Sciences H-1117 Budapest Magyar tudósok krt. 2 Hungary

Abstract

AbstractTetrahydro‐β‐carbolines (THβCs) also known as tryptolines serve as important structural elements in natural products and pharmaceutical compounds, and they are also utilized in drug discovery. They display diverse bioactivities, including anticancer, antifungal, antiparasitic, anti‐ischemic, anti‐inflammatory, and other activities. Besides their pharmacological and biological significance, these structural motifs are also extensively used in the production of other bioactive compounds. This review is intended to summarize recent advancements in the chemistry of this compound class, including the synthesis and the applications as organic synthetic intermediates and bioactive molecules.

Funder

National Natural Science Foundation of China

Government of Jiangsu Province

Publisher

Wiley

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