Synthesis and Structure−Activity Relationships of 3-[(2-Methyl-1,3-thiazol-4-yl)ethynyl]pyridine Analogues as Potent, Noncompetitive Metabotropic Glutamate Receptor Subtype 5 Antagonists; Search for Cocaine Medications-Reference-Cited by-同舟云学术

Synthesis and Structure−Activity Relationships of 3-[(2-Methyl-1,3-thiazol-4-yl)ethynyl]pyridine Analogues as Potent, Noncompetitive Metabotropic Glutamate Receptor Subtype 5 Antagonists; Search for Cocaine Medications

Published:2006-01-07 Issue:3 Volume:49 Page:1080-1100
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Iso Yasuyoshi¹,Grajkowska Ewa¹,Wroblewski Jarda T.¹,Davis Jared¹,Goeders Nicholas E.¹,Johnson Kenneth M.¹,Sanker Subramaniam¹,Roth Bryan L.¹,Tueckmantel Werner¹,Kozikowski Alan P.¹

Affiliation:

1. Drug Discovery Program, Department of Medicinal Chemistry and Pharmacognosy, University of Illinois at Chicago, 833 South Wood Street, Chicago, Illinois 60612, Department of Pharmacology, Georgetown University Medical Center, 3900 Reservoir Road NW, Washington, D.C. 20007, Department of Pharmacology, Toxicology and Neuroscience, LSU Health Sciences Center, Shreveport, Louisiana 71130-3932, Department of Pharmacology and Toxicology, University of Texas Medical Branch, 301 University Boulevard, Galveston,...

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm050570f

Reference53 articles.

1. Phenylglycine derivatives discriminate between mGluR1- and mGluR5-mediated responses

2. 2-Methyl-6-(phenylethynyl)-pyridine (MPEP), a potent, selective and systemically active mGlu5 receptor antagonist

3. 3-[(2-Methyl-1,3-thiazol-4-yl)ethynyl]- pyridine: A Potent and Highly Selective Metabotropic Glutamate Subtype 5 Receptor Antagonist with Anxiolytic Activity

Cited by 81 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Allosteric Modulators of Metabotropic Glutamate Receptors as Novel Therapeutics for Neuropsychiatric Disease;Pharmacological Reviews;2022-06-16

2. Kinetic and system bias as drivers of metabotropic glutamate receptor 5 allosteric modulator pharmacology;Neuropharmacology;2019-05

3. Widely Exploited, Yet Unreported: Regiocontrolled Synthesis and the Suzuki-Miyaura Reactions of Bromooxazole Building Blocks;European Journal of Organic Chemistry;2019-02-27

4. Synthesis toward Bivalent Ligands for the Dopamine D2 and Metabotropic Glutamate 5 Receptors;Journal of Medicinal Chemistry;2018-09-04

5. 2-Aminothiazoles;Privileged Structures in Drug Discovery;2018-03-09