2-Methyl-6-(phenylethynyl)-pyridine (MPEP), a potent, selective and systemically active mGlu5 receptor antagonist

Author:

Gasparini Fabrizio,Lingenhöhl Kurt,Stoehr Natacha,Flor Peter J,Heinrich Micheline,Vranesic Ivo,Biollaz Michel,Allgeier Hans,Heckendorn Roland,Urwyler Stephan,Varney Mark A,Johnson Edwin C,Hess Stephen D,Rao Sara P,Sacaan Aida I,Santori Emily M,Veliçelebi Gönul,Kuhn Rainer

Publisher

Elsevier BV

Subject

Cellular and Molecular Neuroscience,Pharmacology

Reference45 articles.

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2. Baker, R., Clark, B.P., Harris, J.R., Griffey, K.I., Kingston, A.E., Tizzano, J.P., 1998. LY393675, an a-substituted-cyclobutylglycine, is a potent group I metabotropic glutamate receptor antagonist. Soc. Neurosci. Abstr. 229.16.

3. Phenylglycine derivatives as new pharmacological tools for investigating the role of metabotropic glutamate receptors in the central nervous system;Birse;Neuroscience,1993

4. Bowes, M., Panesar, M., Gentry, C., et al., 1999. Anti-hyperalgesic effects of the novel metabotropic glutamate receptor 5 antagonist, methylphenylethynylpyridine, in rat models of inflammatory pain. Br. J. Pharm. (in press).

5. Potassium conductances in hippocampal neurons blocked by excitatory amino acid transmitters;Charpak;Nature,1990

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