Solution pH That Minimizes Self-Association of Three Monoclonal Antibodies Is Strongly Dependent on Ionic Strength-Reference-Cited by-同舟云学术

Solution pH That Minimizes Self-Association of Three Monoclonal Antibodies Is Strongly Dependent on Ionic Strength

Published:2012-02-17 Issue:4 Volume:9 Page:744-751
ISSN:1543-8384
Container-title:Molecular Pharmaceutics
language:en
Short-container-title:Mol. Pharmaceutics

Author:

Sule Shantanu V.¹,Cheung Jason K.²,Antochshuk Valentyn²,Bhalla Amardeep S.²,Narasimhan Chakravarthy²,Blaisdell Steven³,Shameem Mohammed²,Tessier Peter M.¹

Affiliation:

1. Center for Biotechnology & Interdisciplinary Studies, Department of Chemical & Biological Engineering, Rensselaer Polytechnic Institute, Troy, New York 12180, United States

2. Sterile Product Development, Merck Research Laboratories, Summit, New Jersey 07901, United States

3. Analytical Characterization, Merck Research Laboratories, Union, New Jersey 07083, United States

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Pharmaceutical Science,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/mp200448j

Reference63 articles.

1. Principles, approaches, and challenges for predicting protein aggregation rates and shelf life

2. Formulation and delivery issues for monoclonal antibody therapeutics

3. Challenges in the development of high protein concentration formulations