Understanding the Stabilizing Effect of Histidine on mAb Aggregation: A Molecular Dynamics Study-Reference-Cited by-同舟云学术

Understanding the Stabilizing Effect of Histidine on mAb Aggregation: A Molecular Dynamics Study

Published:2022-08-10 Issue:9 Volume:19 Page:3288-3303
ISSN:1543-8384
Container-title:Molecular Pharmaceutics
language:en
Short-container-title:Mol. Pharmaceutics

Author:

Saurabh Suman¹,Kalonia Cavan²,Li Zongyi³^ORCID,Hollowell Peter³,Waigh Thomas³⁴^ORCID,Li Peixun⁵,Webster John⁵,Seddon John M.¹,Lu Jian R.³^ORCID,Bresme Fernando¹^ORCID

Affiliation:

1. Department of Chemistry, Molecular Sciences Research Hub Imperial College, London W12 0BZ, United Kingdom

2. Dosage Form Design and Development, BioPharmaceutical Development, BioPharmaceuticals R&D, AstraZeneca, Gaithersburg 20878, Maryland, United States

3. Biological Physics Group, School of Physics and Astronomy, Faculty of Science and Engineering, Oxford Road, The University of Manchester, Manchester M13 9PL, U.K.

4. Photon Science Institute, The University of Manchester, Manchester M13 9PL, U.K.

5. STFC ISIS Facility, Rutherford Appleton Laboratory, Didcot OX11 0QX, U.K.

Funder

AstraZeneca

Biotechnology and Biological Sciences Research Council

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Pharmaceutical Science,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.molpharmaceut.2c00453

Reference49 articles.