Synthesis and Cytotoxicity of 5-Amino-1-(chloromethyl)-3-[(5,6,7-trimethoxyindol-2-yl)carbonyl]-1,2- dihydro-3H-benz[e]indole (Amino-seco-CBI-TMI) and Related 5-Alkylamino Analogues: New DNA Minor Groove Alkylating Agents-Reference-Cited by-同舟云学术

Synthesis and Cytotoxicity of 5-Amino-1-(chloromethyl)-3-[(5,6,7-trimethoxyindol-2-yl)carbonyl]-1,2- dihydro-3H-benz[e]indole (Amino-seco-CBI-TMI) and Related 5-Alkylamino Analogues: New DNA Minor Groove Alkylating Agents

Published:1998-11-20 Issue:25 Volume:63 Page:9414-9420
ISSN:0022-3263
Container-title:The Journal of Organic Chemistry
language:en
Short-container-title:J. Org. Chem.

Author:

Atwell Graham J.¹,Tercel Moana¹,Boyd Maruta¹,Wilson William R.¹,Denny William A.¹

Affiliation:

1. Auckland Cancer Society Research Centre and Section of Oncology, Department of Pathology, Faculty of Medicine and Health Science, The University of Auckland, Private Bag 92019, Auckland, New Zealand

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/jo981395w

Reference19 articles.

1. The chemistry, mechanism of action and biological properties of CC-1065, a potent antitumor antibiotic.

2. Duocarmycins, Potent Antitumor Antibiotics Produced by Streptomyces sp. Structures and Chemistry.

3. CC-1065 and the Duocarmycins: Understanding their Biological Function through Mechanistic Studies

4. CBI-TMI: Synthesis and Evaluation of a Key Analog of the Duocarmycins. Validation of a Direct Relationship between Chemical Solvolytic Stability and Cytotoxic Potency and Confirmation of the Structural Features Responsible for the Distinguishing Behavior of Enantiomeric Pairs of Agents

5. Synthesis and preliminary evaluation of agents incorporating the pharmacophore of the duocarmycin/pyrindamycin alkylation subunit: identification of the CC-1065/duocarmycin common pharmacophore

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