Disposition of 1-[3-(Aminomethyl)phenyl]-N-[3-fluoro-2‘- (methylsulfonyl)-[1,1‘-biphenyl]-4-yl]-3-(trifluoromethyl)- 1H-pyrazole-5-carboxamide (DPC 423) by Novel Metabolic Pathways. Characterization of Unusual Metabolites by Liquid Chromatography/Mass Spectrometry and NMR-Reference-Cited by-同舟云学术

Disposition of 1-[3-(Aminomethyl)phenyl]-N-[3-fluoro-2‘- (methylsulfonyl)-[1,1‘-biphenyl]-4-yl]-3-(trifluoromethyl)- 1H-pyrazole-5-carboxamide (DPC 423) by Novel Metabolic Pathways. Characterization of Unusual Metabolites by Liquid Chromatography/Mass Spectrometry and NMR

Published:2001-12-07 Issue:1 Volume:15 Page:48-62
ISSN:0893-228X
Container-title:Chemical Research in Toxicology
language:en
Short-container-title:Chem. Res. Toxicol.

Author:

Mutlib Abdul. E.¹,Shockcor John¹,Chen Shiang-Yuan¹,Espina Robert J.¹,Pinto Donald J.¹,Orwat Michael J.¹,Prakash Shimoga R.¹,Gan Liang-Shang¹

Affiliation:

1. Drug Metabolism and Pharmacokinetics Section, DuPont Pharmaceuticals Company, Stine-Haskell Research Center, Newark, Delaware 19714, and Chemical and Physical Sciences Division, DuPont Pharmaceuticals, Experimental Station, Wilmington, Delaware 19880

Publisher

American Chemical Society (ACS)

Subject

Toxicology,General Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/tx0101191

Reference41 articles.

1. Mutlib, A. E., Shockcor, J., Chen, S., Espina, R., Lin, J., Graciani, N., Prakash, S., and Gan, L. (2001) Formation of unusual glutamate conjugates of 1-[3-(aminomethyl) phenyl]-N-[3-fluoro-2‘-(methylsulfonyl)-[1,1‘-biphenyl]-4-yl]-3-(trifluoromethyl)-1H-pyrazole-5-carboxamide (DPC 423) and its analogues. The role of γ-glutamyltranspeptidase in the biotransformation of benzylamines.Drug Metab. Dispos.29, 1296−1306.

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