Activation of the G-Protein-Coupled Receptor 119: A Conformation-Based Hypothesis for Understanding Agonist Response-Reference-Cited by-同舟云学术

Activation of the G-Protein-Coupled Receptor 119: A Conformation-Based Hypothesis for Understanding Agonist Response

Published:2011-03-01 Issue:6 Volume:54 Page:1948-1952
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

McClure Kim F.¹,Darout Etzer¹,Guimarães Cristiano R. W.¹,DeNinno Michael P.¹,Mascitti Vincent¹,Munchhof Michael J.¹,Robinson Ralph P.¹,Kohrt Jeffrey¹,Harris Anthony R.¹,Moore Dianna E.¹,Li Bryan¹,Samp Lacey¹,Lefker Bruce A.¹,Futatsugi Kentaro¹,Kung Daniel¹,Bonin Paul D.¹,Cornelius Peter¹,Wang Ruduan¹,Salter Eben¹,Hornby Sam¹,Kalgutkar Amit S.¹,Chen Yue¹

Affiliation:

1. Department of Medicinal Chemistry, ‡Department of Discovery Biology, and §Department of Drug Metabolism and Pharmaceutical Sciences, Pfizer Global Research and Development, Eastern Point Road, Groton, Connecticut 06340, United States

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm200003p

Reference18 articles.

1. Deorphanization of a G protein-coupled receptor for oleoylethanolamide and its use in the discovery of small-molecule hypophagic agents

2. N-Oleoyldopamine Enhances Glucose Homeostasis through the Activation of GPR119

3. Fatty acid amide signaling molecules

4. Discovery of the First Potent and Orally Efficacious Agonist of the Orphan G-Protein Coupled Receptor 119

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