Synthesis of the NK1 Receptor Antagonist GW597599. Part 3: Development of a Scalable Route to a Key Chirally Pure Arylpiperazine Urea, A Happy End-Reference-Cited by-同舟云学术

Synthesis of the NK1 Receptor Antagonist GW597599. Part 3: Development of a Scalable Route to a Key Chirally Pure Arylpiperazine Urea, A Happy End

Published:2009-10-02 Issue:6 Volume:13 Page:1100-1110
ISSN:1083-6160
Container-title:Organic Process Research & Development
language:en
Short-container-title:Org. Process Res. Dev.

Author:

Guercio Giuseppe¹,Bacchi Sergio¹,Perboni Alcide¹,Leroi Corinne¹,Tinazzi Francesco¹,Bientinesi Ilaria¹,Hourdin Marie¹,Goodyear Michael¹,Curti Stefano¹,Provera Stefano¹,Cimarosti Zadeo¹

Affiliation:

1. Chemical Development and Analytical Chemistry, GlaxoSmithKline Medicines Research Centre, Via Fleming 4, 37135 Verona, Italy, Sanofi-Aventis R&D Centre, 195 route d’Espagne BP 13669, 31036 Toulouse Cedex 1, France, and Pharmasynthese, Process Industrialization - 57 rue Gravetel, 76320 Saint Pierre lès Elbeuf, France

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Physical and Theoretical Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/op9002032

Reference19 articles.

1. Discovery Process and Pharmacological Characterization of 2-(S)-(4-Fluoro-2-methylphenyl)piperazine-1-carboxylic Acid [1-(R)-(3,5-Bis-trifluoromethylphenyl)ethyl]methylamide (Vestipitant) as a Potent, Selective, and Orally Active NK1Receptor Antagonist

2. Synthesis of 3-Phenyl-4-piperidones from Acetophenone by Shapiro and Aza-Michael Reactions and Their Further Derivatization

3. Synthesis of the NK1 Receptor Antagonist GW597599. Part 1: Development of a Scalable Route to a Key Chirally Pure Arylpiperazine

4. Synthesis of the NK1 Receptor Antagonist GW597599. Part 2: Development of a Scalable Route to a Key Chirally Pure Arylpiperazine

5. Synthesis of a Heptapeptide Sequence Derived from Bovine Insulin1

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