Synthesis of the NK1 Receptor Antagonist GW597599. Part 2: Development of a Scalable Route to a Key Chirally Pure Arylpiperazine
Author:
Affiliation:
1. Chemical Development and Analytical Chemistry, GlaxoSmithKline Medicine Research Centre, Via Fleming 4, 37135 Verona, Italy
Publisher
American Chemical Society (ACS)
Subject
Organic Chemistry,Physical and Theoretical Chemistry
Link
https://pubs.acs.org/doi/pdf/10.1021/op8002823
Reference13 articles.
1. Synthesis of the NK1 Receptor Antagonist GW597599. Part 1: Development of a Scalable Route to a Key Chirally Pure Arylpiperazine
2. Burkhardt, E. R.; Corella, J. A., II. U.S. Patent 6,048,985, 2000.
3. Identification of (3R)-7-Hydroxy-N-((1S)-1-{[(3R,4R)-4-(3-hydroxyphenyl)- 3,4-dimethyl-1-piperidinyl]methyl}-2-methylpropyl)-1,2,3,4-tetrahydro- 3-isoquinolinecarboxamide as a Novel Potent and Selective Opioid κ Receptor Antagonist
4. Recent methodologies mediated by sodium borohydride in the reduction of different classes of compounds
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