Identification of (3R)-7-Hydroxy-N-((1S)-1-{[(3R,4R)-4-(3-hydroxyphenyl)- 3,4-dimethyl-1-piperidinyl]methyl}-2-methylpropyl)-1,2,3,4-tetrahydro- 3-isoquinolinecarboxamide as a Novel Potent and Selective Opioid κ Receptor Antagonist-Reference-Cited by-同舟云学术

Identification of (3R)-7-Hydroxy-N-((1S)-1-{[(3R,4R)-4-(3-hydroxyphenyl)- 3,4-dimethyl-1-piperidinyl]methyl}-2-methylpropyl)-1,2,3,4-tetrahydro- 3-isoquinolinecarboxamide as a Novel Potent and Selective Opioid κ Receptor Antagonist

Published:2003-06-11 Issue:14 Volume:46 Page:3127-3137
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Thomas James B.¹,Atkinson Robert N.¹,Vinson N. Ariane¹,Catanzaro Jennifer L.¹,Perretta Carin L.¹,Fix Scott E.¹,Mascarella S. Wayne¹,Rothman Richard B.¹,Xu Heng¹,Dersch Christina M.¹,Cantrell Buddy E.¹,Zimmerman Dennis M.¹,Carroll F. Ivy¹

Affiliation:

1. Chemistry and Life Sciences, Research Triangle Institute, 3040 Cornwallis Road, Research Triangle Park, North Carolina 27709, Clinical Psychopharmacology Section, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, 5500 Nathan Shock Drive, Baltimore, Maryland 21224, and Lilly Research Laboratories, Eli Lilly and Company, Lilly Corporate Center, Indianapolis, Indiana 46285

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm030094y

Reference30 articles.

1. Genetic Mechanisms Determining the Central Visual Pathways of Mice

2. Cloning of a Delta Opioid Receptor by Functional Expression

3. The delta-opioid receptor: isolation of a cDNA by expression cloning and pharmacological characterization.

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