Discovery of Potent, Orally Bioavailable, Small-Molecule Inhibitors of WNT Signaling from a Cell-Based Pathway Screen-Reference-Cited by-同舟云学术

Discovery of Potent, Orally Bioavailable, Small-Molecule Inhibitors of WNT Signaling from a Cell-Based Pathway Screen

Published:2015-02-13 Issue:4 Volume:58 Page:1717-1735
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Mallinger Aurélie¹,Crumpler Simon¹,Pichowicz Mark¹,Waalboer Dennis¹,Stubbs Mark¹,Adeniji-Popoola Olajumoke¹,Wood Bozena²,Smith Elizabeth¹,Thai Ching¹,Henley Alan T.¹,Georgi Katrin³,Court William¹,Hobbs Steve¹,Box Gary¹,Ortiz-Ruiz Maria-Jesus¹,Valenti Melanie¹,De Haven Brandon Alexis¹,TePoele Robert¹,Leuthner Birgitta³,Workman Paul¹,Aherne Wynne¹,Poeschke Oliver³,Dale Trevor²,Wienke Dirk³,Esdar Christina³,Rohdich Felix³,Raynaud Florence¹,Clarke Paul A.¹,Eccles Suzanne A.¹,Stieber Frank³,Schiemann Kai³,Blagg Julian¹

Affiliation:

1. Cancer Research UK Cancer Therapeutics Unit at The Institute of Cancer Research, London SW7 3RP, U.K.

2. School of Bioscience, Cardiff University, Cardiff CF10 3XQ, U.K.

3. Merck KGaA, Merck Serono, 64293 Darmstadt, Germany

Funder

Cancer Research UK

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm501436m