Discovery of Potent, Selective, and Orally Bioavailable Small-Molecule Inhibitors of CDK8 for the Treatment of Cancer-Reference-Cited by-同舟云学术

Discovery of Potent, Selective, and Orally Bioavailable Small-Molecule Inhibitors of CDK8 for the Treatment of Cancer

Published:2023-04-07 Issue:8 Volume:66 Page:5439-5452
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Li Yangguang¹,Liu Yingtao¹,Wu Jianping¹,Liu Xiaosong¹,Wang Lin¹,Wang Ju¹,Yu Jiaojiao¹,Qi Hongyun¹,Qin Luoheng¹,Ding Xiao¹,Ren Feng¹^ORCID,Zhavoronkov Alex¹

Affiliation:

1. Insilico Medicine Shanghai Ltd., Suite 902, Tower C, Changtai Plaza, 2889 Jinke Road, Pudong, Shanghai 201203, China

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.2c01718

Reference36 articles.

1. The mammalian Mediator complex and its role in transcriptional regulation

2. CDK8

3. Revving the Throttle on an Oncogene: CDK8 Takes the Driver Seat: Figure 1.

4. The human Mediator complex: a versatile, genome-wide regulator of transcription

5. The Mediator complex: a central integrator of transcription

Cited by 10 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Enriching Anticancer Drug Pipeline with Potential Inhibitors of Cyclin-Dependent Kinase-8 Identified from Natural Products;OMICS: A Journal of Integrative Biology;2024-09-01

2. Artificial intelligence for small molecule anticancer drug discovery;Expert Opinion on Drug Discovery;2024-06-18

3. Machine learning-aided generative molecular design;Nature Machine Intelligence;2024-06-18

4. Discovery of a Novel and Potent Cyclin-Dependent Kinase 8/19 (CDK8/19) Inhibitor for the Treatment of Cancer;Journal of Medicinal Chemistry;2024-05-01

5. Discovery of macrocyclic CDK2/4/6 inhibitors with improved potency and DMPK properties through a highly efficient macrocyclic drug design platform;Bioorganic Chemistry;2024-05