Design and Synthesis of a 2-Amino-pyridine Derivative as a Potent CDK8 Inhibitor for Anti-colorectal Cancer Therapy
Author:
Affiliation:
1. School of Pharmacy, Inflammation and Immune Mediated Diseases Laboratory of Anhui Province, Anhui Medical University, Hefei 230032, P.R. China
2. School of Chemistry and Materials Engineering, Fuyang Normal University, Fuyang 236037, P.R. China
Funder
National Natural Science Foundation of China
Publisher
American Chemical Society (ACS)
Subject
Drug Discovery,Molecular Medicine
Link
https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.2c01042
Reference42 articles.
1. Colorectal cancer
2. Colorectal cancer
3. APC mutations occur early during colorectal tumorigenesis
4. Molecular causes of colon cancer
5. Inhibition of CDK8 mediator kinase suppresses estrogen dependent transcription and the growth of estrogen receptor positive breast cancer
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